TargetMol

CL2A-SN-38 DCA 1279680-68-0(free base)

Product Code:
 
TAR-T17731L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17731L-1mg1mg£177.00
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Quantity:
TAR-T17731L-5mg5mg£313.00
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TAR-T17731L-10mg10mg£434.00
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TAR-T17731L-25mg25mg£670.00
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Quantity:
TAR-T17731L-50mg50mg£914.00
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Quantity:
TAR-T17731L-100mg100mg£1,211.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .
CAS:
T17731L
Formula:
C77H101Cl4N11O26
Molecular Weight:
1738.49
Purity:
0.9895
SMILES:
OC(=O)C(Cl)Cl.OC(=O)C(Cl)Cl.CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn5cc(CNC(=O)C6CCC(CN7C(=O)C=CC7=O)CC6)nn5)cc4)c3=O)-c2nc2ccc(O)cc12

References

1. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.