TargetMol

2R,4R-Sacubitril

Product Code:
 
TAR-T19111
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19111-1mg1mg£178.00
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TAR-T19111-1mL1 mL * 10 mM (in DMSO)£475.00
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TAR-T19111-5mg5mg£516.00
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This product comes from: United States.
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Further Information

Bioactivity:
2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.
CAS:
766480-48-2
Formula:
C24H29NO5
Molecular Weight:
411.498
Purity:
0.98
SMILES:
CCOC(=O)[C@H](C)C[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O

References

1. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.