TargetMol

2R,4S-Sacubitril

Product Code:
 
TAR-T19112
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19112-1mg1mg£144.00
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TAR-T19112-5mg5mg£291.00
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TAR-T19112-10mg10mg£389.00
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TAR-T19112-25mg25mg£630.00
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TAR-T19112-50mg50mg£870.00
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Quantity:
TAR-T19112-100mg100mg£1,348.00
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This product comes from: United States.
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Further Information

Bioactivity:
2R,4S-Sacubitril is the impurity of Sacubitril which is a neprilysin inhibitor.
CAS:
761373-05-1
Formula:
C24H28NO5 1/2Ca
Molecular Weight:
430.49
Purity:
0.9932
SMILES:
O=C([O-])CCC(N[C@H](C[C@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O.O=C([O-])CCC(N[C@H](C[C@H](C)C(OCC)=O)CC3=CC=C(C4=CC=CC=C4)C=C3)=O.[Ca+2]

References

1. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9. 2. Teyssier VR, et al. Novel O-[11C]-methylated derivatives of the neprilysin inhibitor sacubitril: Radiosynthesis, autoradiography and plasma stability evaluation. Nucl Med Biol. 2021 Nov-Dec;102-103:34-44.