TargetMol

GBR 12783 dihydrochloride

Product Code:
 
TAR-T19337
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19337-1mg1mg£115.00
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TAR-T19337-2mg2mg£132.00
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TAR-T19337-5mg5mg£168.00
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TAR-T19337-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T19337-10mg10mg£213.00
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TAR-T19337-25mg25mg£309.00
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TAR-T19337-50mg50mg£434.00
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TAR-T19337-100mg100mg£597.00
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TAR-T19337-500mg500mg£1,163.00
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Further Information

Bioactivity:
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor. GBR 12783 dihydrochloride inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
CAS:
67469-75-4
Formula:
C28H34Cl2N2O
Molecular Weight:
485.49
Purity:
0.9781
SMILES:
N1(CCN(CC1)CC=CC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl

References

1. Nail-Boucherie K, et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res Cogn Brain Res. 1998 Oct;7(2):203-5. 2. Bonnet JJ, et al. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur J Pharmacol. 1986 Feb 18;121(2):199-209.