TargetMol

GTS-21

Product Code:
 
TAR-T19933
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19933-5mg5mg£850.00
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TAR-T19933-50mg50mg£1,661.00
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Quantity:
TAR-T19933-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
GTS-21 is an α7 nAChR agonist. GTS-21 suppresses inflammation associated with rheumatoid arthritis by inhibiting RA Th1 cell differentiation.
CAS:
148372-04-7
Formula:
C19H20N2O2
Molecular Weight:
308.381
Pathway:
Neuroscience
Purity:
0.98
SMILES:
COc1ccc(C=C2/CCCN=C2c2cccnc2)c(OC)c1
Target:
AChR

References

1. Yue Y, et al. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-?B signaling pathway through the ?7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Dec;29(2):504-512. 2. Kong FJ, et al. Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats. J Surg Res. 2015 Mar;194(1):255-61. 3. Hu Y, et al. Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21. Biomed Res Int. 2014;2014:325875. 4. Callahan PM, Terry AV Jr, Tehim A. Effects of the nicotinic ?7 receptor partial agonist GTS-21 on NMDA-glutamatergic receptor related deficits in sensorimotor gating and recognition memory in rats. Psychopharmacology (Berl). 2014 Sep;231(18):3695-706.