TargetMol

AAL-993

Product Code:
 
TAR-T21593
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T21593-1mg1mg£101.00
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TAR-T21593-5mg5mg£142.00
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TAR-T21593-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T21593-10mg10mg£189.00
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TAR-T21593-25mg25mg£303.00
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TAR-T21593-50mg50mg£436.00
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TAR-T21593-100mg100mg£610.00
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TAR-T21593-500mg500mg£1,219.00
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Further Information

Bioactivity:
AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogenic and antitumor activities.
CAS:
269390-77-4
Formula:
C20H16F3N3O
Molecular Weight:
371.363
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Target:
VEGFR

References

1. Hyun Seung Ban, et al. Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer Lett. 2010 Oct 1;296(1):17-26. 2. Paul W Manley , et al. Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93.