TargetMol

AACOCF3

Product Code:
 
TAR-T21681
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21681-2mg2mg£196.00
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TAR-T21681-1mg1mg£197.00
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TAR-T21681-5mg5mg£262.00
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TAR-T21681-10mg10mg£390.00
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TAR-T21681-25mg25mg£804.00
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TAR-T21681-50mg50mg£1,401.00
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Further Information

Bioactivity:
AACOCF3 is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease.
CAS:
149301-79-1
Formula:
C21H31F3O
Molecular Weight:
356.47
Pathway:
Metabolism
Purity:
0.98
SMILES:
C(CCCC(C(F)(F)F)=O)=CC/C=CC/C=CC/C=CCCCCC
Target:
Phospholipase

References

1. Riendeau D, et al. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J Biol Chem. 1994;269(22):15619-15624. 2. Schanstra JP, et al. Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment. JCI Insight. 2019;4(10):e125638. Published 2019 May 16. 3. Loweth AC, et al. A specific inhibitor of cytosolic phospholipase A2 activity, AACOCF3, inhibits glucose-induced insulin secretion from isolated rat islets. Biochem Biophys Res Commun. 1996;218(2):423-427.