TargetMol

Zoniporide hydrochloride

Product Code:
 
TAR-T21996
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21996-1mg1mg£116.00
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TAR-T21996-5mg5mg£173.00
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TAR-T21996-10mg10mg£219.00
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TAR-T21996-25mg25mg£324.00
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This product comes from: United States.
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Further Information

Bioactivity:
Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets.
CAS:
241800-97-5
Formula:
C17H17ClN6O
Molecular Weight:
356.81
Pathway:
Membrane transporter/Ion channel
Purity:
0.9893
SMILES:
Cl.O=C(NC(=N)N)C=1C=NN(C2=CC=CC3=NC=CC=C32)C1C4CC4
Target:
Sodium Channel

References

1. Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett. 2001 Mar 26;11(6):803-7. 2. Tracey WR, et al. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32.