TargetMol

Adaphostin

Product Code:
 
TAR-T22553
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22553-5mg5mg£122.00
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Quantity:
TAR-T22553-10mg10mg£148.00
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TAR-T22553-25mg25mg£230.00
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TAR-T22553-50mg50mg£334.00
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Quantity:
TAR-T22553-100mg100mg£466.00
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Quantity:
TAR-T22553-500mg500mg£930.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Adaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
CAS:
241127-58-2
Formula:
C24H27NO4
Molecular Weight:
393.483
Pathway:
Cytoskeletal Signaling; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.98
SMILES:
Oc1ccc(O)c(CNc2ccc(cc2)C(=O)OC23CC4CC(CC(C4)C2)C3)c1
Target:
Bcr-Abl

References

1. Svingen PA, et al. Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro. Clin Cancer Res. 2000;6(1):237-249. 2. Chandra J, et al. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood. 2003;102(13):4512-4519. 3. Orsolic N, et al. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Sci. 2006;97(9):952-960.