TargetMol

Anxiolytic/nonsedative agent-1

Product Code:
 
TAR-T23445
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23445-1mg1mg£149.00
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TAR-T23445-2mg2mg£189.00
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TAR-T23445-5mg5mg£227.00
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TAR-T23445-10mg10mg£276.00
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TAR-T23445-25mg25mg£537.00
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Quantity:
TAR-T23445-50mg50mg£736.00
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Quantity:
TAR-T23445-100mg100mg£994.00
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Quantity:
TAR-T23445-500mg500mg£1,902.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Anxiolytic/nonsedative agent-1 is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo.
CAS:
355022-97-8
Formula:
C18H15N3O4
Molecular Weight:
337.33
Pathway:
Membrane transporter/Ion channel; Neuroscience
Purity:
0.9705
SMILES:
C(C(N[C@H](C)C1=CC=CC=C1)=O)(=O)C=2C=3C(NC2)=CC=C(N(=O)=O)C3
Target:
GABA Receptor

References

1. Taliani S, et al. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem. 2009 Jun 25;52(12):3723-34.