TargetMol

Akt-I-1,2

Product Code:
 
TAR-T23695
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23695-1mg1mg£257.00
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Quantity:
TAR-T23695-5mg5mg£450.00
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TAR-T23695-10mg10mg£627.00
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TAR-T23695-25mg25mg£938.00
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Quantity:
TAR-T23695-50mg50mg£1,243.00
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Quantity:
TAR-T23695-100mg100mg£1,653.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
CAS:
473382-50-2
Formula:
C23H22ClN3
Molecular Weight:
375.9
Pathway:
Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
Cl.CC(C)(N)c1ccc(cc1)-c1nc2ccccc2nc1-c1ccccc1
Target:
Akt

References

1. Yamaji M, Ota A, Wahiduzzaman M, Karnan S, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Haniuda M. Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27. PubMed PMID: 28960945; PubMed Central PMCID: PMC5673922. 2. Liebl D, Qi X, Zhe Y, Barnett TC, Teasdale RD. SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell. Front Cell Infect Microbiol. 2017 Jun 15;7:257. doi: 10.3389/fcimb.2017.00257. eCollection 2017. PubMed PMID: 28664153; PubMed Central PMCID: PMC5471308. 3. Zhang Q, Yang M, Qu Z, Zhou J, Jiang Q. Autophagy prevention sensitizes AKTi-1/2-induced anti-hepatocellular carcinoma cell activity in vitro and in vivo. Biochem Biophys Res Commun. 2016 Nov 18;480(3):334-340. doi: 10.1016/j.bbrc.2016.10.043. Epub 2016 Oct 15. PubMed PMID: 27756618. 4. Zhao QW, Zhou YW, Li WX, Kang B, Zhang XQ, Yang Y, Cheng J, Yin SY, Tong Y, He JQ, Yao HP, Zheng M, Wang YJ. Akt mediated phosphorylation of Oct4 is associated with the proliferation of stem like cancer cells. Oncol Rep. 2015 Apr;33(4):1621-9. doi: 10.3892/or.2015.3752. Epub 2015 Jan 27. PubMed PMID: 25625591; PubMed Central PMCID: PMC4358081.