TargetMol

WCK-5153

Product Code:
 
TAR-T23858
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23858-1mg1mg£201.00
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TAR-T23858-5mg5mg£338.00
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TAR-T23858-1mL1 mL * 10 mM (in DMSO)£389.00
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TAR-T23858-10mg10mg£454.00
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TAR-T23858-25mg25mg£699.00
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TAR-T23858-50mg50mg£946.00
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TAR-T23858-100mg100mg£1,251.00
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TAR-T23858-500mg500mg£2,440.00
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Further Information

Bioactivity:
WCK-5153 is an enhancer of β-Lactamase and an inhibitor of PBP2 with antimicrobial activities against Pseudomonas aeruginosa. WCK-5153 can be used in studies about the treatment of serious infections caused by highly drug-resistant Gram-negative pathogens.
CAS:
1436862-38-2
Formula:
C12H19N5O7S
Molecular Weight:
377.37
Pathway:
Microbiology/Virology
Purity:
0.9812
SMILES:
OS(=O)(=O)ON1[C@H]2CN([C@@H](CC2)C(=O)NNC(=O)[C@H]2CCNC2)C1=O
Target:
Antibacterial

References

1. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "?-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-?-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6):e02529-16. 2. Papp-Wallace KM, et al. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using ?-Lactamase Inhibitors and ?-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem. 2018 May 10;61(9):4067-4086. 3. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "?-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-?-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02529-16. 4. Moya B, et al. In Vitro and In Vivo Activities of ?-Lactams in Combination with the Novel ?-Lactam Enhancers Zidebactam and WCK 5153 against Multidrug-Resistant Metallo-?-Lactamase-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e00128-19.