TargetMol

CAY10526

Product Code:
 
TAR-T23861
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23861-1mg1mg£116.00
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TAR-T23861-5mg5mg£182.00
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TAR-T23861-1mL1 mL * 10 mM (in DMSO)£193.00
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TAR-T23861-10mg10mg£269.00
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TAR-T23861-25mg25mg£503.00
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TAR-T23861-50mg50mg£695.00
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Further Information

Bioactivity:
CAY10526 is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.
CAS:
938069-71-7
Formula:
C12H7BrO3S
Molecular Weight:
311.15
Pathway:
GPCR/G Protein; Immunology/Inflammation
Purity:
0.9875
SMILES:
OC1OC(=O)C(Br)=C1c1cc2ccccc2s1
Target:
Prostaglandin Receptor

References

1. Guerrero, M.D., Aquino, M., Bruno, I., et al. Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the ?-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression. Journal of Medicinal Chemistry 50, 2176-2184 (2007). 2. Kim SH, Hashimoto Y, Cho SN, Roszik J, Milton DR, Dal F, Kim SF, Menter DG, Yang P, Ekmekcioglu S, Grimm EA. Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. Pigment Cell Melanoma Res. 2016 May;29(3):297-308. 3. Jongthawin J, Chusorn P, Techasen A, Loilome W, Boonmars T, Thanan R, Puapairoj A, Khuntikeo N, Tassaneeyakul W, Yongvanit P, Namwat N. PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression. Tumour Biol. 2014 Aug;35(8):8051-64. 4. Xu LW, Qian M, Jia RP, Xu Z, Wu JP, Li WC, Huang WB, Chen XG. Expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer. Asian Pac J Cancer Prev. 2012;13(4):1639-44.