TargetMol

SRT1720 hydrochloride

Product Code:
 
TAR-T2412
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2412-1mg1mg£121.00
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TAR-T2412-2mg2mg£136.00
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TAR-T2412-5mg5mg£185.00
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TAR-T2412-1mL1 mL * 10 mM (in DMSO)£282.00
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TAR-T2412-10mg10mg£282.00
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TAR-T2412-25mg25mg£483.00
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TAR-T2412-50mg50mg£545.00
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TAR-T2412-100mg100mg£748.00
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TAR-T2412-200mg200mg£1,002.00
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Further Information

Bioactivity:
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
CAS:
1001645-58-4
Formula:
C25H24ClN7OS
Molecular Weight:
506.03
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.9993
SMILES:
Cl.O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1
Target:
Sirtuin

References

1. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6. 2. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45. 3. Chauhan D, et al. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. Br J Haematol. 2011 Dec;155(5):588-98. 4. Su G, Yang W, Wang S, et al. SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1? and IL-18[J]. Biochemical and Biophysical Research Communications. 2021, 561: 33-39. 5. Chen W, Lin B, Xie S, et al. Naringenin protects RPE cells from NaIO3-induced oxidative damage in vivo and in vitro through up-regulation of SIRT1[J]. Phytomedicine. 2020: 153375. 6. Wu Q, Hu Y, Jiang M, et al. Effect of Autophagy Regulated by Sirt1/FoxO1 Pathway on the Release of Factors Promoting Thrombosis from Vascular Endothelial Cells[J]. International journal of molecular sciences. 2019, 20(17): 4132.