TargetMol

PF-249

Product Code:
 
TAR-T24626
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24626-1mg1mg£140.00
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TAR-T24626-2mg2mg£173.00
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TAR-T24626-5mg5mg£242.00
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TAR-T24626-1mL1 mL * 10 mM (in DMSO)£250.00
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TAR-T24626-10mg10mg£322.00
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TAR-T24626-25mg25mg£499.00
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TAR-T24626-50mg50mg£687.00
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TAR-T24626-100mg100mg£938.00
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Further Information

Bioactivity:
PF-249 is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.
CAS:
1467059-70-6
Formula:
C17H16ClN3O3
Molecular Weight:
345.78
Pathway:
PI3K/Akt/mTOR signaling; Chromatin/Epigenetic
Purity:
0.9702
SMILES:
O=C(O)C1=CNC=2C=C(Cl)C(=CC21)C=3C=CC(=NC3OC)N(C)C
Target:
AMPK

References

1. Cokorinos EC, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25(5):1147-1159.e10. 2. Willows R, et al. Effect of different ?-subunit isoforms on the regulation of AMPK. Biochem J. 2017 May 9;474(10):1741-1754. 3. Salatto CT, et al. Selective Activation of AMPK ?1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J Pharmacol Exp Ther. 2017 May;361(2):303-311. 4. David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383.