TargetMol

TP0427736

Product Code:
 
TAR-T24897
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24897-1mg1mg£181.00
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TAR-T24897-1mL1 mL * 10 mM (in DMSO)£290.00
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TAR-T24897-5mg5mg£294.00
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TAR-T24897-10mg10mg£389.00
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TAR-T24897-25mg25mg£603.00
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TAR-T24897-50mg50mg£830.00
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Further Information

Bioactivity:
TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
CAS:
864374-00-5
Formula:
C14H10N4S2
Molecular Weight:
298.38
Pathway:
Stem Cells
Purity:
0.98
SMILES:
Cc1csc(n1)-c1nc[nH]c1-c1ccc2ncsc2c1
Target:
TGF-beta/Smad

References

1. Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-??induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491. 2. Amada H, et al. Discovery of 7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): a potent and selective transforming growth factor-? type I receptor inhibitor as a topical drug for alopecia. Chem Pharm Bull (Tokyo). 2013;61(3):286-91.