TargetMol

Didemnin B

Product Code:
 
TAR-T25327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25327-1mg1mg£303.00
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TAR-T25327-5mg5mg£645.00
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TAR-T25327-10mg10mg£863.00
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TAR-T25327-25mg25mg£1,259.00
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TAR-T25327-50mg50mg£1,661.00
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This product comes from: United States.
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Further Information

Bioactivity:
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum that has antiviral and antitumor activity.
CAS:
77327-05-0
Formula:
C57H89N7O15
Molecular Weight:
1112.35
Pathway:
Immunology/Inflammation
Purity:
0.984
SMILES:
O=C1N2[C@](C(=O)N(C)[C@@H](CC3=CC=C(OC)C=C3)C(=O)O[C@H](C)[C@H](NC([C@H](N(C(=O)[C@H]4N(C([C@H](C)O)=O)CCC4)C)CC(C)C)=O)C(=O)N[C@]([C@H](CC)C)([C@@H](O)CC(=O)O[C@@H]([C@H](C)C)C(=O)[C@H](C)C(=O)N[C@H]1CC(C)C)[H])(CCC2)[H]
Target:
Antiviral

References

1. Potts MB, et al. Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B. Nat Chem Biol. 2015 Jun;11(6):401-8. 2. Hetherington AM, et al. Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice. Physiol Rep. 2016 Sep;4(17). 3. Henne WA, et al. Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):709-12. 4. Stewart JA, et al. A phase I clinical trial of didemnin B. Cancer. 1991;68(12):2550-2554.