TargetMol

Tecastemizole

Product Code:
 
TAR-T26253
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26253-1mg1mg£140.00
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TAR-T26253-5mg5mg£242.00
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TAR-T26253-1mL1 mL * 10 mM (in DMSO)£259.00
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TAR-T26253-10mg10mg£322.00
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TAR-T26253-25mg25mg£499.00
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TAR-T26253-50mg50mg£687.00
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TAR-T26253-100mg100mg£938.00
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TAR-T26253-500mg500mg£1,805.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tecastemizole is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects.
CAS:
75970-99-9
Formula:
C19H21FN4
Molecular Weight:
324.403
Pathway:
GPCR/G Protein; Neuroscience; Immunology/Inflammation
Purity:
0.9966
SMILES:
Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc23)cc1
Target:
Histamine Receptor

References

1. Lever R, et al. Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17. 2. Schneider E, et al. Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole. J Clin Pharm Ther. 2006 Jun;31(3):261-73. 3. Vlaar T, et al. Sustainable synthesis of diverse privileged heterocycles by palladium-catalyzed aerobic oxidative isocyanide insertion. Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13058-61. 4. Paakkari I. Cardiotoxicity of new antihistamines and cisapride. Toxicol Lett. 2002 Feb 28;127(1-3):279-84. Review.