TargetMol

Triparanol

Product Code:
 
TAR-T26296
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26296-1mg1mg£470.00
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TAR-T26296-5mg5mg£978.00
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TAR-T26296-1mL1 mL * 10 mM (in DMSO)£1,042.00
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TAR-T26296-10mg10mg£1,291.00
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TAR-T26296-25mg25mg£1,886.00
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TAR-T26296-50mg50mg£2,472.00
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TAR-T26296-100mg100mg£3,380.00
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This product comes from: United States.
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Further Information

Bioactivity:
Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.
CAS:
78-41-1
Formula:
C27H32ClNO2
Molecular Weight:
438.01
Pathway:
Stem Cells; GPCR/G Protein; Apoptosis
Purity:
0.98
SMILES:
CCN(CC)CCOc1ccc(cc1)C(O)(Cc1ccc(Cl)cc1)c1ccc(C)cc1
Target:
Apoptosis; Hedgehog/Smoothened

References

1. Officioso A, et al. Triggering of Erythrocyte Death by Triparanol. Toxins (Basel). 2015 Aug 24;7(8):3359-71. 2. Bi X, et al. Triparanol suppresses human tumor growth in vitro and in vivo [published correction appears in Biochem Biophys Res Commun. 2012 Nov 2;427(4):808]. Biochem Biophys Res Commun. 2012;425(3):613-618. 3. Ramu A, Glaubiger D, Fuks Z. Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues. Cancer Res. 1984 Oct;44(10):4392-5. 4. Mizuno GR, Chapman CJ, Chipault JR, Pfeiffer DR. Lipid composition and (Na+ + K+)-ATPase activity in rat lens during triparanol-induced cataract formation. Biochim Biophys Acta. 1981 Jun 9;644(1):1-12.