TargetMol

Ani9

Product Code:
 
TAR-T26630
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26630-1mg1mg£97.00
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TAR-T26630-5mg5mg£132.00
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TAR-T26630-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T26630-10mg10mg£177.00
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TAR-T26630-25mg25mg£298.00
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TAR-T26630-50mg50mg£454.00
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TAR-T26630-100mg100mg£624.00
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TAR-T26630-500mg500mg£1,259.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the treatment of ancer, hypertension, pain, diarrhea and asthma.
CAS:
356102-14-2
Formula:
C17H17ClN2O3
Molecular Weight:
332.78
Pathway:
Membrane transporter/Ion channel
Purity:
0.9872
SMILES:
COc1ccccc1C=NNC(=O)COc1ccc(Cl)cc1C
Target:
Chloride channel

References

1. Hahn A, et al. Cellular distribution and function of ion channels involved in transport processes in rat tracheal epithelium. Physiol Rep. 2017 Jun;5(12). pii: e13290. 2. Truong EC, et al. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 Jun 8;60(11):4626-4635. 3. Seo Y, et al. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2. PLoS One. 2016 May 24;11(5):e0155771.