TargetMol

PRT062607 hydrochloride

Product Code:
 
TAR-T2696
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2696-1mg1mg£115.00
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TAR-T2696-2mg2mg£133.00
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TAR-T2696-5mg5mg£174.00
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TAR-T2696-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T2696-10mg10mg£229.00
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TAR-T2696-25mg25mg£347.00
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TAR-T2696-50mg50mg£494.00
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TAR-T2696-200mg200mg£871.00
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Further Information

Bioactivity:
PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
CAS:
1370261-97-4
Formula:
C19H24ClN9O
Molecular Weight:
429.91
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; MAPK
Purity:
0.9993
SMILES:
Cl.N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Target:
MLK; Syk; Src

References

1. Coffey G, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Feb;340(2):350-9. 2. Hoellenriegel J, et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia. 2012 Jul;26(7):1576-83.