TargetMol

KN-93

Product Code:
 
TAR-T2697
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2697-1mg1mg£112.00
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TAR-T2697-2mg2mg£128.00
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TAR-T2697-5mg5mg£163.00
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TAR-T2697-1mL1 mL * 10 mM (in DMSO)£174.00
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TAR-T2697-10mg10mg£197.00
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TAR-T2697-25mg25mg£329.00
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TAR-T2697-50mg50mg£483.00
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TAR-T2697-100mg100mg£658.00
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This product comes from: United States.
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Further Information

Bioactivity:
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
CAS:
139298-40-1
Formula:
C26H29ClN2O4S
Molecular Weight:
501.04
Pathway:
Autophagy; Neuroscience
Purity:
0.9978
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CCO)c1ccccc1CN(C)CC=Cc1ccc(Cl)cc1
Target:
CaMK; Autophagy

References

1. Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70. 2. Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15. 3. Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006. 4. Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39(3):1196-208. 5. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1[J]. Frontiers in Pharmacology. 2021, 11: 2233. 6. Xuexian Fang, Hao Wang, Dan Han, Enjun Xie, Xiang Yang, Jiayu Wei, Shanshan Gu et al. Ferroptosis as a target for protection against cardiomyopathy [J]. Proceedings of the National Academy of Sciences of the United States of America . 2019 Feb 12;116(7):2672-2680.