TargetMol

Crisdesalazine

Product Code:
 
TAR-T27084
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27084-1mg1mg£227.00
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TAR-T27084-5mg5mg£422.00
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TAR-T27084-10mg10mg£589.00
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TAR-T27084-25mg25mg£863.00
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TAR-T27084-50mg50mg£1,179.00
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Quantity:
TAR-T27084-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
Crisdesalazine is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span.
CAS:
927685-43-6
Formula:
C16H14F3NO3
Molecular Weight:
325.287
Pathway:
GPCR/G Protein; Immunology/Inflammation
Purity:
0.98
SMILES:
OC(=O)c1cc(NCCc2ccc(cc2)C(F)(F)F)ccc1O
Target:
Prostaglandin Receptor

References

1. Baek IS, et al. AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease. Exp Neurobiol. 2013 Mar;22(1):31-7. 1. Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL. AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease. Exp Neurobiol. 2013 Mar;22(1):31-7. doi: 10.5607/en.2013.22.1.31. PubMed PMID: 23585720; PubMed Central PMCID: PMC3620456. 2. Shin JH, Lee YA, Lee JK, Lee YB, Cho W, Im DS, Lee JH, Yun BS, Springer JE, Gwag BJ. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61. doi: 10.1111/j.1471-4159.2012.07771.x. PubMed PMID: 22537108. 2. Shin JH, et al. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.