TargetMol

DDD85646

Product Code:
 
TAR-T27135
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27135-1mg1mg£148.00
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TAR-T27135-5mg5mg£324.00
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TAR-T27135-1mL1 mL * 10 mM (in DMSO)£349.00
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TAR-T27135-10mg10mg£465.00
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TAR-T27135-25mg25mg£646.00
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TAR-T27135-50mg50mg£870.00
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Quantity:
TAR-T27135-100mg100mg£1,171.00
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This product comes from: United States.
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Further Information

Bioactivity:
DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.
CAS:
1215010-55-1
Formula:
C21H24Cl2N6O2S
Molecular Weight:
495.42
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Target:
Parasite

References

1. Bayliss T, Robinson DA, Smith VC, Brand S, McElroy SP, Torrie LS, Mpamhanga C, Norval S, Stojanovski L, Brenk R, Frearson JA, Read KD, Gilbert IH, Wyatt PG. Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors. J Med Chem. 2017 Nov 10. doi: 10.1021/acs.jmedchem.7b01255. [Epub ahead of print] PubMed PMID: 29125744. 2. Roberts AJ, Fairlamb AH. The N-myristoylome of Trypanosoma cruzi. Sci Rep. 2016 Aug 5;6:31078. doi: 10.1038/srep31078. PubMed PMID: 27492267; PubMed Central PMCID: PMC4974623. 3. Robinson DA, Wyatt PG. Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase. Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):586-93. doi: 10.1107/S2053230X15003040. Epub 2015 Apr 21. PubMed PMID: 25945713; PubMed Central PMCID: PMC4427169. 4. Fang W, Robinson DA, Raimi OG, Blair DE, Harrison JR, Lockhart DE, Torrie LS, Ruda GF, Wyatt PG, Gilbert IH, van Aalten DM. N-myristoyltransferase is a cell wall target in Aspergillus fumigatus. ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb 27. PubMed PMID: 25706802; PubMed Central PMCID: PMC4477619.