TargetMol

MI-2-2

Product Code:
 
TAR-T28036
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T28036-1mg1mg£148.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28036-5mg5mg£264.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
CAS:
1454920-20-7
Formula:
C17H20F3N5S2
Molecular Weight:
415.5
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
CC1(C)CN=C(S1)N1CCN(CC1)c1ncnc2sc(CC(F)(F)F)cc12
Target:
Histone Methyltransferase

References

1. Shi A, et al. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood. 2012;120(23):4461-4469. 2. Ren J, et al. Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-6. 3. Vedadi M, et al. Targeting human SET1/MLL family of proteins. Protein Sci. 2017 Apr;26(4):662-676.