TargetMol

NS9283

Product Code:
 
TAR-T28199
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28199-1mg1mg£101.00
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TAR-T28199-5mg5mg£148.00
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TAR-T28199-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T28199-10mg10mg£189.00
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TAR-T28199-25mg25mg£322.00
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TAR-T28199-50mg50mg£466.00
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TAR-T28199-100mg100mg£651.00
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TAR-T28199-500mg500mg£1,291.00
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Further Information

Bioactivity:
NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.
CAS:
913830-15-6
Formula:
C14H8N4O
Molecular Weight:
248.245
Pathway:
Neuroscience
Purity:
0.9881
SMILES:
N#Cc1cccc(c1)-c1nc(no1)-c1cccnc1
Target:
AChR

References

1. Maurer JJ, et al. Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283. Psychopharmacology (Berl). 2017 Feb;234(3):475-484. 2. Wang J, et al. Promoting activity of (?4)3(?2)2 nicotinic cholinergic receptors reduces ethanol consumption. Neuropsychopharmacology. 2020 Jan;45(2):301-308. 3. Grupe M, et al. Neuropharmacological modulation of the P3-like event-related potential in a rat two-tone auditory discrimination task with modafinil and NS9283, a positive allosteric modulator of ?4?2 nAChRs. Neuropharmacology. 2014 Apr;79:444-55. 4. M Grupe, et al. Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (?4)3(?2) 2nicotinic ACh receptors. Br J Pharmacol. 2013 Apr;168(8):2000-10.