TargetMol

PSNCBAM-1

Product Code:
 
TAR-T28468
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28468-1mg1mg£125.00
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TAR-T28468-5mg5mg£189.00
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TAR-T28468-1mL1 mL * 10 mM (in DMSO)£204.00
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TAR-T28468-10mg10mg£245.00
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TAR-T28468-25mg25mg£359.00
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TAR-T28468-50mg50mg£499.00
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TAR-T28468-100mg100mg£688.00
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  • Further Information
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Further Information

Bioactivity:
PSNCBAM-1 is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
CAS:
877202-74-9
Formula:
C22H21ClN4O
Molecular Weight:
392.89
Pathway:
GPCR/G Protein
Purity:
0.9818
SMILES:
Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(n2)N2CCCC2)cc1
Target:
Cannabinoid Receptor

References

1. Wang X, et al. Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum. Mol Pharmacol. 2011 Apr;79(4):758-67. 2. Horswill JG, et al. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br J Pharmacol. 2007 Nov;152(5):805-14. 3. Cawston EE, et al. Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol. 2013 Oct;170(4):893-907. 4. German N, et al. Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J Med Chem. 2014 Sep 25;57(18):7758-69.