TargetMol

Sepin-1

Product Code:
 
TAR-T28754
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28754-1mg1mg£95.00
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Quantity:
TAR-T28754-5mg5mg£135.00
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TAR-T28754-10mg10mg£173.00
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TAR-T28754-25mg25mg£303.00
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TAR-T28754-50mg50mg£454.00
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Quantity:
TAR-T28754-100mg100mg£624.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sepin-1 is a noncompetitive inhibitor of separase with an IC50 of 14.8 ?M. Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apoptosis.
CAS:
163126-81-6
Formula:
C9H9N3O4
Molecular Weight:
223.188
Purity:
0.98
SMILES:
CC1(C)[N+]([O-])=c2ccc(cc2=[N+]1[O-])[N+]([O-])=O

References

1. Do HT, Zhang N, Pati D, Gilbertson SR. Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4446-50. 2. Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC, Pati D. Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J Biomol Screen. 2014 Jul;19(6):878-89.