TargetMol

VPC-13566

Product Code:
 
TAR-T29111
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29111-1mg1mg£149.00
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Quantity:
TAR-T29111-5mg5mg£241.00
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TAR-T29111-1mL1 mL * 10 mM (in DMSO)£246.00
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TAR-T29111-10mg10mg£309.00
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TAR-T29111-25mg25mg£487.00
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TAR-T29111-50mg50mg£672.00
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Quantity:
TAR-T29111-100mg100mg£922.00
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Quantity:
TAR-T29111-500mg500mg£1,749.00
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Quantity:
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Further Information

Bioactivity:
VPC-13566 is a BF3-specific small molecule, which effectively inhibited the androgen receptor transcriptional activity and displaced the BAG1L peptide from the BF3 pocket. VPC-13566 inhibits the growth of various prostate cancer cell lines and reduces the growth of AR-dependent prostate cancer xenograft tumors in mice.
CAS:
218464-59-6
Formula:
C18H14N2
Molecular Weight:
258.324
Pathway:
Endocrinology/Hormones
Purity:
0.9937
SMILES:
Cc1cccc2c(c[nH]c12)-c1ccc2ccccc2n1
Target:
Androgen Receptor

References

1. Lallous N, et al. Targeting Binding Function-3 of the Androgen Receptor Blocks Its Co-Chaperone Interactions, Nuclear Translocation, and Activation. Mol Cancer Ther. 2016 Dec;15(12):2936-2945. Epub 2016 Oct 7.