TargetMol

N-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea

Product Code:
 
TAR-T29522L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29522L-1mg1mg£227.00
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TAR-T29522L-2mg2mg£306.00
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TAR-T29522L-5mg5mg£430.00
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TAR-T29522L-1mL1 mL * 10 mM (in DMSO)£439.00
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TAR-T29522L-10mg10mg£599.00
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TAR-T29522L-25mg25mg£863.00
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TAR-T29522L-50mg50mg£1,179.00
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TAR-T29522L-100mg100mg£1,589.00
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TAR-T29522L-500mg500mg£3,107.00
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Further Information

Bioactivity:
N-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea is a potent TRPV1 antagonist, blocking activation of TRPV1 by capsaicin with the IC50 of 123 nM.
CAS:
808756-70-9
Formula:
C21H24N4O
Molecular Weight:
348.44
Pathway:
Membrane transporter/Ion channel
Purity:
0.9978
SMILES:
N(C(NC1=C2C(NN=C2)=CC=C1)=O)[C@@H]3C=4C(=CC(C(C)(C)C)=CC4)CC3
Target:
TRP/TRPV Channel

References

1. Gomtsyan A, et al. Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management. J Med Chem. 2008 Feb 14;51(3):392-5.