TargetMol

Negletein

Product Code:
 
TAR-T2S0843
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2S0843-1mg1mg£173.00
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TAR-T2S0843-1mL1 mL * 10 mM (in DMSO)£282.00
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TAR-T2S0843-5mg5mg£293.00
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TAR-T2S0843-10mg10mg£450.00
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TAR-T2S0843-25mg25mg£680.00
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TAR-T2S0843-50mg50mg£863.00
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TAR-T2S0843-100mg100mg£1,179.00
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TAR-T2S0843-500mg500mg£2,311.00
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Further Information

Bioactivity:
1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.
CAS:
29550-13-8
Formula:
C16H12O5
Molecular Weight:
284.267
Pathway:
Immunology/Inflammation; Apoptosis
Purity:
0.9992
SMILES:
COc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
Target:
IL Receptor; TNF; NOS; Interleukin

References

1. Phan, C., Sabaratnam, V., Bovicelli, P., Righi, G., & Saso, L. (2016). Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells.?Biofactors,?42(6), 591-599. doi: 10.1002/biof.1296