TargetMol

HhAntag

Product Code:
 
TAR-T3460
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3460-1mg1mg£121.00
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TAR-T3460-2mg2mg£161.00
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TAR-T3460-5mg5mg£236.00
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TAR-T3460-1mL1 mL * 10 mM (in DMSO)£251.00
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TAR-T3460-10mg10mg£356.00
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TAR-T3460-25mg25mg£543.00
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TAR-T3460-50mg50mg£759.00
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TAR-T3460-100mg100mg£1,018.00
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This product comes from: United States.
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Further Information

Bioactivity:
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.
CAS:
496794-70-8
Formula:
C24H23ClN4O3
Molecular Weight:
450.92
Pathway:
Stem Cells; GPCR/G Protein
Purity:
0.9573
SMILES:
COc1cc(OC)cc(c1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2cc(ccc2[nH]1)N(C)C
Target:
Hedgehog/Smoothened; Smo

References

Yauch, Robert L.; Gould, Stephen E.; Scales, Suzie J.; et al. A paracrine requirement for hedgehog signalling in cancer. Nature (London, United Kingdom) (2008), 455(7211), 406-410. Mahindroo, Neeraj; Connelly, Michele C.; Punchihewa, Chandanamali; et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorganic & Medicinal Chemistry (2010), 18(13), 4801-4811. Li H, Ou J, Li Y, et al. ISX-9 potentiates CaMKII?-mediated BMAL1 activation to enhance circadian amplitude. Communications Biology. 2022, 5(1): 1-13. Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30.