TargetMol

Vesnarinone

Product Code:
 
TAR-T3465
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3465-1mg1mg£98.00
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TAR-T3465-2mg2mg£109.00
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TAR-T3465-5mg5mg£135.00
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TAR-T3465-10mg10mg£168.00
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TAR-T3465-25mg25mg£230.00
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TAR-T3465-50mg50mg£367.00
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TAR-T3465-100mg100mg£511.00
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This product comes from: United States.
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Further Information

Bioactivity:
Vesnarinone (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.
CAS:
81840-15-5
Formula:
C22H25N3O4
Molecular Weight:
395.459
Pathway:
Microbiology/Virology; Proteases/Proteasome; Metabolism
Purity:
0.9669
SMILES:
COc1ccc(cc1OC)C(=O)N1CCN(CC1)c1ccc2NC(=O)CCc2c1
Target:
HIV Protease; PDE

References

Cavusoglu E, et al. Vesnarinone: a new inotropic agent for treating congestive heart failure. J Card Fail. 1995 Jun;1(3):249-57. Matsumori A, et al. Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure. Circulation. 1994 Mar;89(3):955-8. Inage M, et al. Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin. Int J Biol Sci. 2009;5(4):304-10. Katayama Y, et al. Inhibitory effects of Vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line. J Pharmacol Exp Ther. 2000 Jul;294(1):339-46.