TargetMol

TPX-0046

Product Code:
 
TAR-T35384
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35384-1mg1mg£198.00
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TAR-T35384-2mg2mg£257.00
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TAR-T35384-5mg5mg£369.00
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TAR-T35384-10mg10mg£535.00
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TAR-T35384-25mg25mg£1,058.00
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TAR-T35384-50mg50mg£1,428.00
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Quantity:
TAR-T35384-100mg100mg£1,902.00
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Further Information

Bioactivity:
TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.
CAS:
2359650-19-2
Formula:
C21H21FN6O3
Molecular Weight:
424.43
Pathway:
Apoptosis; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.98
SMILES:
O=C1NC[C@@H](C)OC2=NC=C(F)C=C2CN3C4=NC5=C1C=NN5C=C4O[C@@]6([H])[C@]3([H])CCC6
Target:
c-RET; Src

References

Repetto M, et al. The return of RET GateKeeper mutations? an in-silico exploratory analysis of potential resistance mechanisms to novel RET macrocyclic inhibitor TPX-0046. Invest New Drugs. 2022 May 25.