TargetMol

IMR-1A

Product Code:
 
TAR-T3540
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3540-1mg1mg£149.00
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TAR-T3540-5mg5mg£269.00
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TAR-T3540-1mL1 mL * 10 mM (in DMSO)£273.00
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TAR-T3540-10mg10mg£367.00
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TAR-T3540-25mg25mg£570.00
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TAR-T3540-50mg50mg£781.00
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TAR-T3540-100mg100mg£1,026.00
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TAR-T3540-500mg500mg£2,022.00
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This product comes from: United States.
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Further Information

Bioactivity:
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
CAS:
331862-41-0
Formula:
C13H11NO5S2
Molecular Weight:
325.35
Pathway:
Neuroscience; Stem Cells; Proteases/Proteasome; Metabolism
Purity:
0.9986
SMILES:
COc1cc(C=C2/SC(=S)NC2=O)ccc1OCC(O)=O
Target:
Gamma-secretase; Drug Metabolite

References

Tang Y, Song H, Wang Z, et al.Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.Cell Reports.2022, 39(2): 110622. Tang Y, Song H, Wang Z, et al. Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations. Cell Reports. 2022, 39(2): 110622 Astudillo L,et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.