TargetMol

N-desmethyl Olanzapine

Product Code:
 
TAR-T35716
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35716-1mg1mg£99.00
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TAR-T35716-5mg5mg£209.00
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TAR-T35716-10mg10mg£272.00
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TAR-T35716-25mg25mg£499.00
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TAR-T35716-50mg50mg£688.00
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This product comes from: United States.
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Further Information

Bioactivity:
N-desmethyl Olanzapine is a major metabolite of the atypical antipsychotic agent olanzapine .1,2N-desmethyl Olanzapine is formedviaoxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoform CYP1A2.1
CAS:
161696-76-0
Formula:
C16H18N4S
Molecular Weight:
298.41
Pathway:
Metabolism
Purity:
0.98
SMILES:
Cc1cc2c(Nc3ccccc3N=C2N2CCNCC2)s1
Target:
Drug Metabolite|P450

References

Chiu JA, et al. Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detection. J Pharm Biomed Anal. 1996;14(5):609-615. Ring BJ, et al. Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine. J Pharmacol Exp Ther. 1996;276(2):658-666. Skogh E, et al. Therapeutic drug monitoring data on olanzapine and its N-demethyl metabolite in the naturalistic clinical setting. Ther Drug Monit. 2002;24(4):518-526.