TargetMol

Gliovirin

Product Code:
 
TAR-T35741
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T35741-1mg1mg£626.00
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Further Information

Bioactivity:
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decreases phorbol 12-myristate 13-acetate (TPA)- and ionomycin-induced increased expression of COX-2 (IC50= 1 μM) and protein levels of IL-2 in Jurkat cells (IC50= 5.2 μM).1
CAS:
83912-90-7
Formula:
C20H20N2O8S2
Molecular Weight:
480.5
Purity:
0.98
SMILES:
[H][C@@]([C@H](SS[C@]12C[C@]34O[C@H]3C=C[C@H]([C@]54[H])O)C6=CC=C(C(OC)=C6O)OC)(C(N2O5)=O)NC1=O

References

Howell, C.R., and Stipanovic, R.D.Gliovirin, a new antibiotic from Gliocladium virens, and its role in the biological control of Pythium ultimumCan. J. Microbiol.29(3)321-324(1983) Iwatsuki, M., Otoguro, K., Ishiyama, A., et al.In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationshipsJ. Antibiot. (Tokyo)63(10)619-622(2010) Rether, J., Serwe, A., Anke, T., et al.Inhibition of inducible tumor necrosis factor-? expression by the fungal epipolythiodiketopiperazine gliovirinBiol. Chem.388(6)627-637(2007)