TargetMol

BMS-986176

Product Code:
 
TAR-T35856
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35856-1mg1mg£211.00
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TAR-T35856-5mg5mg£369.00
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TAR-T35856-1mL1 mL * 10 mM (in DMSO)£389.00
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TAR-T35856-10mg10mg£517.00
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TAR-T35856-25mg25mg£790.00
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TAR-T35856-50mg50mg£1,050.00
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Quantity:
TAR-T35856-100mg100mg£1,396.00
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Quantity:
TAR-T35856-500mg500mg£2,713.00
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Further Information

Bioactivity:
AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
CAS:
1815613-42-3
Formula:
C19H23F4N3O
Molecular Weight:
385.4
Pathway:
Neuroscience
Purity:
0.98
SMILES:
N/A
Target:
AAK1 (AP2 associated kinase 1)

References

Guanglin Luo, et al. Discovery of ( S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022 Mar 24;65(6):4457-4480. Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.