D-myo-Inositol-1,4,5-triphosphate (sodium salt)

Product Code:

TAR-T35935

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

No additional charges, what you see is what you pay! *

Code	Size	Price

TAR-T35935-1mg

1mg

£551.00

Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.

Quantity:

TAR-T35935-5mg

5mg

£1,572.00

Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.

Quantity:

Prices exclude any Taxes / VAT

How to order with us Contact us

Further Information

Bioactivity:

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate.[1][2] It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.[2][3]

CAS:

141611-10-1

Formula:

C6H12O15P3?3Na

Molecular Weight:

486

Pathway:

Metabolism|Membrane transporter/Ion channel

Purity:

0.98

SMILES:

O[C@@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]

Target:

Calcium Channel

Documents

References

Anraku K, et al. Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry. 2010;49(25):5109-5116. Exton JH. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol. 1996;36:481-509. Streb H, et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature. 1983;306(5938):67-69. Yoshida Y, et al. Structure and function of inositol 1,4,5-trisphosphate receptor. Jpn J Pharmacol. 1997;74(2):125-137.