TargetMol

K-TMZ

Product Code:
 
TAR-T36100
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T36100-1mg1mg£174.00
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TAR-T36100-5mg5mg£335.00
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Quantity:
TAR-T36100-10mg10mg£495.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
CAS:
0
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0