TargetMol

coumarin-SAHA

Product Code:
 
TAR-T36105
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36105-1mg1mg£103.00
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TAR-T36105-5mg5mg£158.00
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TAR-T36105-10mg10mg£203.00
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TAR-T36105-25mg25mg£323.00
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Further Information

Bioactivity:
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
CAS:
1260635-77-5
Formula:
C18H22N2O5
Molecular Weight:
346.4
Purity:
0.98
SMILES:
N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide

References

Marks, P.A., and Breslow, R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nat. Biotechnol. 25(1), 84-90 (2007). Singh, R.K., Mandal, T., Balasubramanian, N., et al. Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors. Anal. Biochem. 408(2), 309-315 (2011).