TargetMol

11β-Prostaglandin E2

Product Code:
 
TAR-T36144
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36144-1mg1mg£129.00
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TAR-T36144-5mg5mg£329.00
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TAR-T36144-10mg10mg£525.00
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Further Information

Bioactivity:
11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3]
CAS:
38310-90-6
Formula:
C20H32O5
Molecular Weight:
352.471
Purity:
0.98
SMILES:
CCCCC[C@H](O)C=C[C@H]1[C@@H](O)CC(=O)[C@@H]1CC=C/CCCC(O)=O

References

Itoh, S., Lu, R., Bao, Y., et al. Structural determinants of substrates for the prostaglandin transporter PGT. Molecular Pharmacology 50, 736-742 (1996). Raisz, L.G., and Woodiel, F.N. Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. Prostaglandins 37, 229-235 (1989). Dray, F., and Heaulme, M. Prostaglandins of the E series inhibit release of noradrenaline in rat hypothalamus by a mechanism unrelated to classical ?2 adrenergic presynaptic inhibition. Neuropharmacology 23, 457-462 (1984).