TargetMol

Cobimetinib

Product Code:
 
TAR-T3623
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3623-1mg1mg£98.00
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TAR-T3623-2mg2mg£108.00
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TAR-T3623-5mg5mg£132.00
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TAR-T3623-1mL1 mL * 10 mM (in DMSO)£143.00
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TAR-T3623-10mg10mg£148.00
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TAR-T3623-25mg25mg£217.00
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TAR-T3623-50mg50mg£304.00
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TAR-T3623-100mg100mg£454.00
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TAR-T3623-500mg500mg£863.00
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Further Information

Bioactivity:
Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation.
CAS:
934660-93-2
Formula:
C21H21F3IN3O2
Molecular Weight:
531.318
Pathway:
MAPK; Apoptosis
Purity:
0.9998
SMILES:
OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1
Target:
Apoptosis; MEK

References

Baudy AR, et al. EJNMMI Res. 2012, 2(1), 22. Hoeflich KP, et al. Cancer Res. 2012, 72(1), 210-219. Meng Y, Lv T, Zhang J, et al.Temporospatial inhibition of Erk signaling is required for lymphatic valve formation.Signal Transduction and Targeted Therapy.2023, 8(1): 342.