TargetMol

Dihydrodiol-Ibrutinib

Product Code:
 
TAR-T36429
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36429-1mg1mg£164.00
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TAR-T36429-5mg5mg£304.00
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TAR-T36429-10mg10mg£418.00
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This product comes from: United States.
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Further Information

Bioactivity:
PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A.
CAS:
1654820-87-7
Formula:
C25H26N6O4
Molecular Weight:
474.5
Purity:
0.98
SMILES:
O=C(C(CO)O)N1CCC[C@@](C1)([H])N2N=C(C3=C2N=CN=C3N)C4=CC=C(OC5=CC=CC=C5)C=C4O=C(C(CO)O)N1CCC[C@@](C1)([H])N2N=C(C3=C2N=CN=C3N)C4=CC=C(OC5=CC=CC=C5)C=C4

References

Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)