TargetMol

Gramicidin A

Product Code:
 
TAR-T36439
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36439-1mg1mg£148.00
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TAR-T36439-5mg5mg£270.00
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Further Information

Bioactivity:
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. It induces degradation of hypoxia inducible factor 1 α (HIF-1α) in HEK293 cells and reduces growth in a human renal cell carcinoma mouse xenograft model when administered at a dose of 0.22 mg/kg three times per week. Gramicidin A has commonly been used to study channel structure and function.
CAS:
11029-61-1
Formula:
C19H33N5O6
Molecular Weight:
427.502
Pathway:
Angiogenesis|Chromatin/Epigenetic|Microbiology/Virology
Purity:
0.98
SMILES:
CC(C)C[C@@H](NC=O)C(=O)N[CH]C(=O)N[C@H](CC(C)C)C(=O)N[CH]C(=O)NCCO
Target:
HIF|Parasite|Antibacterial

References

David JM, et al. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013;12(11):2296-2307. David JM, et al. Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. Mol Cancer Ther. 2014;13(4):788-799. Takada Y, et al. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nat Commun. 2020;11(1):4935.