TargetMol

GS-441524 tris-isobutyryl ester

Product Code:
 
TAR-T36440
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36440-1mg1mg£201.00
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Further Information

Bioactivity:
GS-441524tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50value of 0.26 μM.
CAS:
2563617-99-0
Formula:
C24H31N5O7
Molecular Weight:
501.5
Purity:
0.98
SMILES:
O=C(C(C)C)OC[C@@H]1[C@@H](OC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@@](C#N)(C2=CC=C3N2N=CN=C3N)O1

References

Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1?-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey model of RSVJ. Med. Chem.64(8)5001-5017(2021)