TargetMol

COR659

Product Code:
 
TAR-T36520
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36520-1mg1mg£148.00
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TAR-T36520-5mg5mg£269.00
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TAR-T36520-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T36520-10mg10mg£402.00
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TAR-T36520-25mg25mg£626.00
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TAR-T36520-50mg50mg£862.00
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TAR-T36520-100mg100mg£1,139.00
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Further Information

Bioactivity:
COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor.
CAS:
544450-68-2
Formula:
C16H16ClNO3S
Molecular Weight:
337.82
Pathway:
Membrane transporter/Ion channel; GPCR/G Protein; Neuroscience
Purity:
0.9956
SMILES:
O=C(C1=C(NC(C2=CC=C(Cl)C=C2)=O)SC(C)=C1CC)OC
Target:
Cannabinoid Receptor; GABA Receptor

References

Paola Maccioni, et al. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA B and cannabinoid CB 1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543. Paola Maccioni, et al. Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues. Alcohol. 2019 Mar;75:55-66. Francesca Ferlenghi, et al. The GABA B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci. 2020 Dec 1;155:105544.