TargetMol

APY29

Product Code:
 
TAR-T3654
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3654-2mg2mg£99.00
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TAR-T3654-5mg5mg£118.00
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TAR-T3654-1mL1 mL * 10 mM (in DMSO)£123.00
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TAR-T3654-10mg10mg£148.00
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TAR-T3654-25mg25mg£220.00
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TAR-T3654-50mg50mg£325.00
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TAR-T3654-100mg100mg£530.00
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TAR-T3654-500mg500mg£1,026.00
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This product comes from: United States.
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Further Information

Bioactivity:
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
CAS:
1216665-49-4
Formula:
C17H16N8
Molecular Weight:
332.371
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9657
SMILES:
C1CC1c1cc(Nc2ccnc(Nc3ccc4nc[nH]c4c3)n2)n[nH]1
Target:
IRE1

References

Wang, L., Perera, B., Hari, S., Bhhatarai, B., Backes, B., & Seeliger, M. et al. (2012). Divergent allosteric control of the IRE1? endoribonuclease using kinase inhibitors.?Nature Chemical Biology,?8(12), 982-989. doi: 10.1038/nchembio.1094 Yuan J, Yao C, Tang J, et al. Enhanced GRP78 protein expression via the IRE1?/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021, 462: 152962.