TargetMol

Citarinostat

Product Code:
 
TAR-T3661
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3661-1mg1mg£106.00
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TAR-T3661-5mg5mg£148.00
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TAR-T3661-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T3661-10mg10mg£168.00
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TAR-T3661-25mg25mg£249.00
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TAR-T3661-50mg50mg£369.00
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TAR-T3661-100mg100mg£503.00
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Further Information

Bioactivity:
ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis.
CAS:
1316215-12-9
Formula:
C24H26ClN5O3
Molecular Weight:
467.95
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9895
SMILES:
ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1Cl
Target:
HDAC

References

Huang P, et al. Oncotarget. 2017, 8(2):2694-2707.