TargetMol

Dehydro Nifedipine

Product Code:
 
TAR-T36665
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36665-1mg1mg£111.00
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TAR-T36665-5mg5mg£171.00
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TAR-T36665-10mg10mg£222.00
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TAR-T36665-50mg50mg£448.00
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This product comes from: United States.
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Further Information

Bioactivity:
Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.
CAS:
67035-22-7
Formula:
C17H16N2O6
Molecular Weight:
344.323
Purity:
0.98
SMILES:
COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c1ccccc1[N+]([O-])=O

References

Shimada T, et al. Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci U S A. 1989;86(2):462-465.